Subway & Bus. Almost all subways stop at 14th St. The nearest are the A and E lines at 8th Ave, and the 1, 2 and 3 lines at 7th Ave. Then either walk, or take 14 St crosstown (M-14) bus, west across 14th St to 10th Ave.
Taxi. The best way to get here! A short cab ride from midtown, downtown, and all points in between.
Car. During daytime hours parking restrictions make it very difficult to find a space. During evening and night hours parking is generally available, but finding a spot can be "challenging."